IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes
作者： Cécile Apert , Paola Romagnoli , Joost P. M. van Meerwijk
DOI: 10.1007/S13238-017-0425-3
关键词:
摘要: Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in maintenance of tolerance immune-system to self and innocuous non-self. Most Treg that are critical for self, develop as an independent T-cell lineage from common cell precursors thymus. In this organ, their differentiation requires signals receptor antigen, co-stimulatory molecules, well cytokine-receptors. Here we focus on cytokines implicated thymic development Treg, with particular emphasis roles interleukin-2 (IL-2) IL-15. The more recently appreciated involvement TGF-β is also briefly discussed. Finally, discuss how cytokine-dependence allows temporal, quantitative, potentially qualitative modulation process.
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