Ethinyl Estradiol and Conjugated Estrogens as Postcoital Contraceptives

摘要: Five study centers enrolled 1,311 women seeking postcoital contraception methods. Ethinyl estradiol was administered at 5 mg/day and conjugated estrogens 30 for five consecutive days starting within 72 hours of unprotected coitus. Eleven pregnancies occurred in the 976 who had a single coitus midcycle. Based on published information, 69 would have been expected if no contraceptives were used. Although both treatments effective preventing pregnancy, ethinyl seemed to be more effective. At two alternately prescribing drugs, none 137 treated with became pregnant, while six 132 given pregnant. Women whose treatment commenced first day lower pregnancy rates than those medication delayed second or third regardless which drug Side effects mainly limited nausea that 70% vomiting experienced by 33% all treated. ( JAMA 244:1336-1339, 1980)