Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs

摘要: A diagnosis of advanced ovarian cancer is the beginning a long and arduous journey for patient. Worldwide, approximately half individuals undergoing therapy will succumb to disease, or consequences treatment. Well-known widely-used chemotherapeutic agents such as cisplatin, paclitaxel, 5-fluorouracil, doxorubicin are toxic both non-cancerous cells, have debilitating side effects Therefore, development new targeted anticancer therapies that can selectively kill cells while sparing surrounding healthy tissues essential develop more effective therapies. We developed class synthetic curcumin analogs, diarylidenyl-piperidones (DAPs), which higher activity enhanced bio-absorption than curcumin. The DAP backbone structure exhibits cytotoxic (anticancer) activity, whereas N-hydroxypyrroline (-NOH) moiety found on some variants functions cellular- tissue-specific modulator (antioxidant) cytotoxicity. DAPs has been evaluated using number cell lines, safety in lines. Both variations compounds showed similar levels death however with -NOH modification were less cells. selective cytotoxicity DAP–NOH suggests they be useful safe agents. This article reviews key findings our work compounds, compares this currently used therapy.