Chapter 21 Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination

摘要: Demyelination contributes to the loss of function consequent central nervous system (CNS) injury. Optimizing remyelination through transplantation myelin-producing cells may offer a pragmatic approach restoring meaningful neurological function. An unlimited source cell suitable for such therapy can be derived from embryonic stem (ES) cells, which are both pluripotent and genetically flexible. Here we review work our group showing that neural precursor ES these into injured spinal cord leads some recovery We have further examined optimized methods enriching oligodendrocyte differentiation cells. cell-derived oligodendrocytes capable rapid myelination in mixed neuron/glia cultures. When transplanted adult rodents, neural-induced differentiating myelinating host axons. The role will discussed context regeneration strategies.