Zinc requirement for macrophage function: effect of zinc deficiency on uptake and killing of a protozoan parasite.

摘要: The effects of suboptimal levels zinc, an essential trace element, on the ability murine macrophages to associate with and destroy a pathogenic parasite, Trypanosoma cruzi, were evaluated. Young adult A/J mice fed zinc-deficient, zinc-adequate or restricted amounts diet for 28 days. On basis weight loss parakeratosis, zinc-deficient further divided into moderately severely Day 28. Both percentage mouse peritoneal (MPM) associated parasites number per 100 significantly lower from deficient compared MPM diet. Furthermore, both groups killed fewer internalized than did mice. Pretreatment 5 micrograms zinc/ml 30 min completely restored their capacity take up kill parasites. Other metals tested, including copper, manganese nickel, failed reverse zinc deficiency. These results point important role in biochemical events macrophage uptake killing parasite.