Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system.

摘要: The recent use of genetically engineered knockout (Ko) and knockin (Kin) animals for neurotransmitter receptor genes, in particular, nicotinic acetylcholine receptors (nAChRs) the brain, has provided a powerful alternative to classical pharmacological approach. These animal models are not only useful order reexamine refine results derived from studies, but they do also provide unique opportunity determine subunit composition which modulate various brain functions. Ultimately, this knowledge will be valuable process designing new drugs that mimic effects nicotine on several important pathologies or smoking cessation therapies. In review, we present data obtained studies mutant contributed our understanding role nAChRs central nervous system (CNS). advantages pitfalls Ko discussed.