Nanocomposite powders of hydroxyapatite-graphene oxide for biological applications
作者： Camila C Lopes , Wagner A Pinheiro , Daniel Navarro da Rocha , José G Neves , Américo Bortolazzo Correr
DOI: 10.1016/J.CERAMINT.2020.11.107
关键词:
摘要: Abstract The repair of bone fractures is a clinical challenge for patients with impaired healing, such as osteoporosis. Currently, different strategies have been developed to design new biomaterials, enhancing their interactions biological systems and conducting the cellular behavior in desired direction help fracture healing. In present work, hydroxyapatite-graphene oxide (HA-GO) nanocomposites were produced morphological physicochemical influences addition 0.5 wt%, 1.0 wt% 1.5 wt% GO HA observed. FEG-SEM TEM analyses HA-GO showed nanoparticles adhered surface sheets, suggesting an effective method form nanostructured graphene-based biomaterials. As confirmation, by Raman, FTIR TGA demonstrated strong affinity between GO, according increase concentration from 0.5 wt% nanocomposites. Also, order evaluate under microenvironment, vitro bioactivity indirect cytotoxicity tests performed. confirmed positive results properties nanocomposite that even decrease hDPSCs viability proliferation, when increasing concentration, high level cell was exhibited These suggested potential bioactive graft promising biomaterial tissue regeneration, compared pure HA.
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