Nifedipine and conventional therapy for unstable angina pectoris: a randomized, double-blind comparison.

摘要: To characterize the potential of nifedipine in therapy unstable angina pectoris we implemented a blinded, randomly assigned, titrated schedule conventional (propranolol, if not contraindicated, and isosorbide dinitrate) or for 14 days 126 patients hospitalized coronary care unit ischemic chest pain less than 45 min duration. There were no significant differences between conventionally nifedipine-treated with regard to (1) time relief as judged by life table analysis, (2) decrease anginal attacks per 24 hr from day 0 2 (-2.5 +/- 0.4 vs; -2.8 0.3 nifedipine), (3) number nitroglycerin tablets consumed (-2.0 0.5 vs -2.1 therapy), (4) percentage requiring morphine on 1 (13% 21% (5) who developed infarction (14% both groups). Among 27 did respond initial (n = 13) 14), five each group became free when opposite (either therapy) was added. In subgroup 67 receiving propranolol before randomization, addition more effective controlling an increase (p .026). 59 prior propranolol, initiation produced rapid alone .001), which tended heart rate. Thus, study population whole equivalent angina, although this overall equivalence may result combination superiority previously beta-blocker beta-blockers.