Mechanisms of Skeletal Muscle Weakness
作者： Håkan Westerblad , Nicolas Place , Takashi Yamada
DOI: 10.1007/978-1-4419-6366-6_16
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摘要: Skeletal muscle weakness is an important feature of numerous -pathological conditions and it may also be a component in normal ageing. Decreased muscular strength can due to decreased mass and/or intrinsic defects the cells. In this chapter we will discuss force production mechanisms skeletal We mainly use data from mouse disease models exemplify at various sites cellular activation-contraction pathway. show that depending on underlying problem, Ca²(+) release sarcoplasmic reticulum, reduced myofibrillar sensitivity ability cross-bridges generate force.
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