Mitigation approaches to combat the flu pandemic.

摘要: Management of flu pandemic is a perpetual challenge for the medical fraternity since time immemorial. Animal to human transmission has been observed thrice in last century within an average range 11-39 years antigenic recycling. The recent outbreak influenza A (H1N1, also termed as swine flu), first reported Mexico on April 26, 2009, occurred forty year (July 1968). Within less than 50 days, it assumed proportions (phase VI) affecting over 76 countries with 163 deaths/35,928 cases (as 15(th) June 2009). It indicated re-emergence genetically reassorted virus having strains endemic humans, and avian (H5N1). World Health Organisation (WHO) member states have already pulled up their socks geared combat such criticalities. Earlier outbreaks (H5N1) different led WHO develop preparedness strategies national/regional plans preparedness. Numerous factors related climatic conditions, socio-economic strata, governance sharing information/logistics at all levels considered critical indicators monitoring dynamics escalation towards situation.The National Disaster Authority (NDMA), Government India, active cooperation UN agencies other stakeholders/experts formulated concept paper role nonhealth service providers during pandemics 2008 released national guidelines - management biological disasters July 2008. These enumerate that success endeavors like pharmaceutical (anti-viral Oseltamivir Zanamivir therapies), nonpharmaceutical interventions vaccination development etc., largely depends level resistance offered by mutagenic viral strain rationale use pharmaco therapeutic interventions. This article describes mitigation approach its effective implementation national, state local levels.