Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats
作者： E. Adeghate , A. S. Ponery
DOI: 10.1046/J.1365-2826.2002.00811.X
关键词:
摘要: Ghrelin is a novel 28-amino acid gut-brain peptide, which was first isolated in the rat stomach. This study examined effect of ghrelin on insulin secretion from pancreas normal and diabetic rats. Diabetes induced by single dose streptozotocin. Four weeks after induction diabetes, pancreatic tissue fragments rats were treated with different concentrations (10(-12), 10(-9) 10(-6) M) ghrelin. evoked large significant increases both In rats, diltiazem (calcium channel antagonist) or combination atropine (muscarinic cholinergic receptor antagonist), propranolol (beta-adrenergic yohimbine (alpha2-adrenergic significantly reduced stimulatory secretion. Diltiazem failed to inhibit ghrelin-evoked release pancreas. Ghrelin-immunoreactivity cells observed 2.6% 3.8% total cell population islet Langerhans respectively.
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