Lipid alterations and their reversion in the central nervous system of growing rats deficient in essential fatty acids

摘要: Essential fatty acid (EFA) deficiency modifies several biological parameters, i.e., growth, metabolic rate and water balance induces functional changes in liver, kidney lung tissues. The brain reported the literature are generally smaller than those observed other However, EFA initiated rats prior to birth continued for a prolonged period of time results decreased weight, lipid phospholipid content considerable polyunsaturated distribution, especially ethanolamine phosphoglyceride fraction. unsaturation level this is maintained at constant spite distribution changes. Brain analyses, carried out various intervals deficient animals, indicate that weights already reduced 10-day-old rats, phospholipids decrease, males after three months, begin rather early. latter consist decrease tetraenes increase trienes triene-tetraene ratios as early 10 days, hexaenes six an pentaenes, which elevated but usually disappear months age. Similar myelin. induced not completely reversed upon return normal diet.