Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5α-cholest-8(14)-en-3β-ol-15-one in rats and mice
作者： George J. Schroepfer , Daniel Monger , Allan S. Taylor , Jeffrey S. Chamberlain , Edward J. Parish
DOI: 10.1016/0006-291X(77)91424-3
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摘要: Abstract 5α-Cholest-8(14)-en-3β-ol-15-one, at a level of 0.1% in low cholesterol diet has been shown to have profound hypocholesterolemic effect rats. In one experiment the mean serum (mg per 100 ml ± S.E.M.) decreased from 71.2 0.9 36.9 3.3 after 7 days on diet. second value 86.4 1.2 33.4 3.9 8 ketone-containing The effects 15-ketosterol levels were significantly (p
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