Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival.
作者： Beibei Wu , Sarah Piloto , Weihua Zeng , Nate P Hoverter , Thomas F Schilling
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摘要: T-cell factor/lymphoid enhancer factor (TCF/LEF) proteins regulate transcription by recruiting β-catenin and its associated co-regulators. Whether TCF/LEFs also recruit more factors through independent, direct interactions is not well understood. Here we discover Ring Finger Protein 14 (RNF14) as a new binding partner for all TCF/LEF factors. We show that RNF14 positively regulates Wnt signalling in human cancer cells an vivo zebrafish model to target promoters with TCF stabilizing recruitment. depletion experiments demonstrate it crucial colon cell survival. Therefore, have identified key interacting of TCF/β-catenin complexes gene transcription.
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