Impact of Individual Antiretroviral Drugs on the Risk of Myocardial Infarction in Human Immunodeficiency Virus-Infected Patients A Case-Control Study Nested Within the French Hospital Database on HIV ANRS Cohort CO4

作者: Sylvie Lang , Murielle Mary-Krause , Laurent Cotte , Jacques Gilquin , Marialuisa Partisani

DOI: 10.1001/ARCHINTERNMED.2010.197

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摘要: Background: The role of exposure to specific antiretroviral drugs on risk myocardial infarction in human immunodeficiency virus (HIV)–infected patients is debated the literature. Methods: To assess whether we confirmed association between abacavir and (MI) estimate impact other nucleoside reverse transcriptase inhibitors (NRTIs), protease (PIs), non-NRTIs MI, conducted a case-control study nested within French Hospital Database HIV. Cases (n=289) were who, January 2000 December 2006, had prospectively recorded first definite or probable MI. Up 5 controls (n=884), matched for age, sex, clinical center, selected at random with replacement among no history MI already enrolled database when was diagnosed corresponding case. Conditional logistic regression models used adjust potential confounders. Results: Short-term/recent associated an increased overall sample (odds ratios [ORs], 2.01; 95% confidence interval [CI], 1.113.64) but not subset cases (81%) who did use cocaine intravenous (1.27; 0.64-2.49). Cumulative all PIs except saquinavir significant amprenavir/fosamprenavir without ritonavir (OR, 1.53; CI, 1.21-1.94 per year) lopinavir (1.33; 1.09-1.61 year). Exposure nonNRTIs Conclusion: by cumulative studied particularly ritonavir, whereas cannot be considered causal.

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