Cisplatin

摘要: Cisplatin is a metal coordination compound that was approved for clinical use in treating testicular cancer 5 years ago. Although early trials showed marked gastrointestinal and renal toxicities, treatment-related morbidity has been significantly alleviated with modern antiemetic therapy adequate pretreatment hydration. More recent studies of cisplatin have shown broad range activity provide better understanding the drug's pharmacology, mechanism action, toxicity. Variations dosage mode administration as well development analogues are being currently studied.