Lipid metabolic studies in oophorectomised women: effects on serum lipids and lipoproteins of three synthetic progestogens

摘要: Abstract Norethisterone acetate, medroxyprogesterone acetate and levonorgestrel were administered to oophorectomised women evaluate the effects they have on lipid metabolism. Blood samples drawn after a 3 wk period without hormone therapy each progestogen. Serum lipoprotein lipids followed an oral glucose tolerance test with blood plasma insulin determinations performed. The nortestosterone derivatives, norethisterone levonorgestrel, decreased high density cholesterol as well α-lipoproteincholesterol, while 17-hydroxyprogesterone derivative did not. impaired tolerance. A difference between derivatives having effect lipoproteins is suggested