Conjugate addition of 1,3-dicarbonyl compounds to maleimides using a chiral C2-symmetric bis(2-aminobenzimidazole) as recyclable organocatalyst.
作者： Eduardo Gómez-Torres , Diego A. Alonso , Enrique Gómez-Bengoa , Carmen Nájera
DOI: 10.1021/OL202599H
关键词:
摘要: The recyclable chiral 2-aminobenzimidazole-derived organocatalyst 1f efficiently promotes the room temperature asymmetric conjugate addition of 1,3-diketones, β-ketoesters, and malonates to maleimide N-substituted maleimides, affording corresponding Michael adducts in excellent yields enantioselectivities even at gram scale.
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sci-hub.se 参考文章(20)
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