High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature
作者： Kevin L. Bentley , Sharon Stranford , Shan Liao , Rawad M. Mounzer , Frank H. Ruddle
DOI: 10.1007/978-1-4419-6612-4_4
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摘要: Lymphotoxin (LT) is crucial for the regulation of HEV adhesion molecules MAdCAM-1 and PNAd a sulfotransferase, GlcNAc6ST-2 (gene symbol Chst4); here called HEC-6ST. Following immunization, some HEVs express markers both (PNAd) LVs (LYVE-1). In order to evaluate this process in real time, we have developed mice transgenic construct that consists an specific gene driving green fluorescent reporter (eGFP). These concurrence with endogenous PNAd. Additional lymphatic vessel constructs are development. will provide material vivo imaging allow us interaction LVs.
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