IL17A Antibodies and Antagonists for Veterinary Use

摘要: Provided are various embodiments relating to anti-IL17A antibodies and IL17Ra ECD polypeptides that bind IL17A. In embodiments, such or can be used in methods treat IL17-induced conditions subjects, as humans companion animals, canines, felines, equines. Also provided IgG Fc variant having one more amino acid substitutions for reducing binding C1q and/or CD16. some the variants comprising (e.g., fusion described herein) may have reduced complement-mediated immune responses antibody-dependent cell-mediated cytotoxicity.