作者: Joseph Sisko , Jerry Leroy Adams , Jeffrey Charles Boehm , John Cheung-Lun Lee , Timothy F. Gallagher
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摘要: This invention relates to certain 5-(optionally substituted aryl or heteroaryl)-4-(optionally heteroaryl)-1-(optionally heterocyclyl heterocyclylalkyl) 1- optionally alkyl alkenyl -imidazoles and derivatives thereof. Synthetic processes for the preparation of said tri-substituted imidazoles is described. The aforementioned are useful treating cytokine mediated diseases. compounds incorporated into pharmaceutical compositions use in related