Effect of olive leaf extract treatment on doxorubicin-induced cardiac, hepatic and renal toxicity in rats
作者： Alkın Kumral , Murat Giriş , Merva Soluk-Tekkeşin , Vakur Olgaç , Semra Doğru-Abbasoğlu
DOI: 10.1016/J.PATHOPHYS.2015.04.002
关键词:
摘要: Doxorubicin (DOX) is known to increase in oxidative stress several organs. Olive leaf extract (OLE) has potent antioxidant effects; therefore, we evaluated the ability of OLE reduce DOX-induced toxicity heart, liver, and kidneys rats. DOX (30 mg/kg; i.p.) was administered rats, which were sacrificed 4 days after DOX. The rats received (6 12 mL/L drinking water) for days. Serum cardiac troponin I (cTnI) levels, alanine aminotransferase (ALT), aspartate (AST) activities, urea creatinine as well prooxidant status organs measured. found serum markers that indicate tissue injury, malondialdehyde (MDA), diene conjugate (DC), protein carbonyl (PC) decrease glutathione (GSH) levels Histopathologic changes also evaluated. OLE, especially 1000, led decreases cTnI ALT AST amelioration histopathologic findings. Decreases MDA, DC, PC, increases GSH observed DOX-treated due OLE. We conclude treatment may be effective decreasing cardiac, hepatic renal injury. © 2015 Elsevier B.V. All rights reserved.
pathophysiologyjournal.com参考文章(33)
Abraham Z. Reznick, Lester Packer, [38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay Methods in Enzymology. ,vol. 233, pp. 357- 363 ,(1994) , 10.1016/S0076-6879(94)33041-7
Noha Ahmed El Boghdady, Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell Biochemistry and Function. ,vol. 31, pp. 344- 351 ,(2013) , 10.1002/CBF.2907
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
Katsuhisa Omagari, Shigeko Kato, Koichi Tsuneyama, Hideki Hatta, Miki Sato, Mizuho Hamasaki, Yukiko Sadakane, Takehiro Tashiro, Mitsue Fukuhata, Yuji Miyata, Shizuka Tamaru, Kazunari Tanaka, Masatoshi Mune, Olive leaf extract prevents spontaneous occurrence of non-alcoholic steatohepatitis in SHR/NDmcr-cp rats. Pathology. ,vol. 42, pp. 66- 72 ,(2010) , 10.3109/00313020903434389
Dragana Dekanski, Vesna Selaković, Vesna Piperski, Željka Radulović, Andrej Korenić, Lidija Radenović, Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine. ,vol. 18, pp. 1137- 1143 ,(2011) , 10.1016/J.PHYMED.2011.05.010
Richard A. Lawrence, Raymond F. Burk, Glutathione peroxidase activity in selenium-deficient rat liver Biochemical and Biophysical Research Communications. ,vol. 71, pp. 952- 958 ,(1976) , 10.1016/0006-291X(76)90747-6
Ioanna Andreadou, Fragiska Sigala, Efstathios K. Iliodromitis, Maria Papaefthimiou, Constantinos Sigalas, Nektarios Aligiannis, Paraskevi Savvari, Vassilis Gorgoulis, Efstathios Papalabros, Dimitrios. Th. Kremastinos, Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress. Journal of Molecular and Cellular Cardiology. ,vol. 42, pp. 549- 558 ,(2007) , 10.1016/J.YJMCC.2006.11.016
Nirav Patel, Cecil Joseph, George B. Corcoran, Sidhartha D. Ray, Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. Toxicology and Applied Pharmacology. ,vol. 245, pp. 143- 152 ,(2010) , 10.1016/J.TAAP.2010.02.002
Hemant Poudyal, Fiona Campbell, Lindsay Brown, Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate–, High Fat–Fed Rats Journal of Nutrition. ,vol. 140, pp. 946- 953 ,(2010) , 10.3945/JN.109.117812
Mohamed A. El-Moselhy, Azza A.K. El-Sheikh, Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity Biomedicine & Pharmacotherapy. ,vol. 68, pp. 101- 110 ,(2014) , 10.1016/J.BIOPHA.2013.09.001