Fetal/placental regulation of maternal melatonin in rats.
作者： Hiroshi Tamura , Hisako Takayama , Yasuhiko Nakamura , Russel J. Reiter , Norihiro Sugino
DOI: 10.1111/J.1600-079X.2007.00537.X
关键词:
摘要: We investigated how maternal melatonin is regulated in pregnant rats. To examine the involvement of conceptus (fetus and placenta) serum concentrations, number conceptuses was experimentally reduced to one on day 7 pregnancy (1-conceptus group). Maternal circulating nighttime levels increased toward 21 rapidly decreased non-pregnancy after parturition, whereas 1-conceptus group were significantly lower than normal bearing dams more 10 conceptuses. When fetuses removed by fetectomy (all but not placentae) 12 pregnancy, concentrations decreased. source melatonin, mRNA expression N-acetyltransferase (NAT), which a late limiting enzyme for synthesis, examined placenta fetal pineal. NAT expressed negligible pineal gland fetus compared with mother's gland. effect placental hormones production, conditioned medium, made incubating 20 injected into from 17 pregnancy. Injection medium control values charcoal treatment abolished stimulatory medium. In conclusion, during
sci-hub.se 参考文章(38)
James Olcese, The mammalian pineal gland and reproduction. Controversies and strategies for future research. Advances in Experimental Medicine and Biology. ,vol. 377, pp. 1- 14 ,(1995) , 10.1007/978-1-4899-0952-7_1
M. Møller, P. Phansuwan-Pujito, G. Mick, Expression of Neurotransmitter Receptor Subtypes and Subunits in the Mammalian Pineal Gland The Pineal Gland and Its Hormones. pp. 1- 11 ,(1995) , 10.1007/978-1-4615-1911-9_1
Y L Chan, A Lin, J McNally, D Peleg, O Meyuhas, I G Wool, The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein. Journal of Biological Chemistry. ,vol. 262, pp. 1111- 1115 ,(1987) , 10.1016/S0021-9258(19)75757-3
F.M. Reis, F. Petraglia, The placenta as a neuroendocrine organ. Frontiers of Hormone Research. ,vol. 27, pp. 216- 228 ,(2001) , 10.1159/000061028
D.P. Cardinali, María I. Vacas, María I. Keller Sarmiento, Graciela S. Etchegoyen, Elba N. Pereyra, H.E. Chuluyan, Neuroendocrine integrative mechanisms in mammalian pineal gland: effects of steroid and adenohypophysial hormones on melatonin synthesis in vitro. Journal of Steroid Biochemistry. ,vol. 27, pp. 565- 571 ,(1987) , 10.1016/0022-4731(87)90355-4
K. OCHIAI, H. KATO, P. A. KELLY, I. ROTHCHILD, The importance of a luteolytic effect of the pituitary in understanding the placental control of the rat corpus luteum. Endocrinology. ,vol. 112, pp. 1687- 1695 ,(1983) , 10.1210/ENDO-112-5-1687
Maria San Martin, André Bogdan, Yvan Touitou, Day-night differences in the effects of gonadal hormones on melatonin release from perifused rat pineals. Evidence of a circadian control Steroids. ,vol. 61, pp. 27- 32 ,(1996) , 10.1016/0039-128X(95)00172-M
Adel RA Abd-Allah, El-Sayed M El-Sayed, Mohamed H Abdel-Wahab, Farid MA Hamada, Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. Pharmacological Research. ,vol. 47, pp. 349- 354 ,(2003) , 10.1016/S1043-6618(03)00014-8
M.D. Maldonado, F. Murillo-Cabezas, M. P. Terron, L. J. Flores, D. X. Tan, L. C. Manchester, R. J. Reiter, The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. Journal of Pineal Research. ,vol. 42, pp. 1- 11 ,(2007) , 10.1111/J.1600-079X.2006.00376.X
Russel J. Reiter, The ageing pineal gland and its physiological consequences. BioEssays. ,vol. 14, pp. 169- 175 ,(1992) , 10.1002/BIES.950140307