CXCL9 promotes prostate cancer progression through inhibition of cytokines from T cells
作者： Shanfeng Tan , Kai Wang , Fuguang Sun , Yang Li , Yisheng Gao
关键词:
摘要: Chemokines have been demonstrated to serve an important role in a variety of diseases, particularly tumor progression. There numerous studies that reported T cells major roles However, the function CXC motif chemokine ligand 9 (CXCL9) prostate cancer remains unknown. The present study aimed investigate CXCL9 cancer. A mouse model was generated by treating C57/BL-6 and B6.Cg-Selplgtm1Fur/J mice with 3,2′-dimethyl 4-aminobiphenyl (DMAB). Hematoxylin eosin staining detected histopathological alterations tissues. Immunohistochemistry (IHC) determined cell proliferation mice. Flow cytometry used detect C57+DMAB or CXCL9+DMAB Immunofluorescence revealed there positive expression interleukin-6 (IL-6) transforming growth factor (TGF)-β survival rates analyzed. association clinical stages also evaluated. Results pathology were significantly greater compared Compared mice, number peripheral blood spleen reduced. IHC IL-6 TGF-β downregulated rate decreased In addition, reverse transcription-quantitative polymerase chain reaction analysis mRNA samples positively associated pathological conclusion, may promote progression via inhibition cytokines from cells.
spandidospublications.net参考文章(26)
Misako Matsumoto, Hiroyuki Oshiumi, Tsukasa Seya, Antiviral responses induced by the TLR3 pathway. Reviews in Medical Virology. ,vol. 21, pp. 67- 77 ,(2011) , 10.1002/RMV.680
Shinako Araki, Yohei Omori, Dominic Lyn, Rajendra K. Singh, David M. Meinbach, Yekutiel Sandman, Vinata B. Lokeshwar, Bal L. Lokeshwar, Interleukin-8 Is a Molecular Determinant of Androgen Independence and Progression in Prostate Cancer Cancer Research. ,vol. 67, pp. 6854- 6862 ,(2007) , 10.1158/0008-5472.CAN-07-1162
Samuli Rautava, Lei Lu, N. Nanda Nanthakumar, Alix Dubert-Ferrandon, W. Allan Walker, TGF-β2 Induces Maturation of Immature Human Intestinal Epithelial Cells and Inhibits Inflammatory Cytokine Responses Induced Via the NF-κB Pathway Journal of Pediatric Gastroenterology and Nutrition. ,vol. 54, pp. 630- 638 ,(2012) , 10.1097/MPG.0B013E31823E7C29
Muthulekha Swamydas, Krista Ricci, Stephen L. Rego, Didier Dréau, Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases Cell Adhesion & Migration. ,vol. 7, pp. 315- 324 ,(2013) , 10.4161/CAM.25138
Baijun Dong, Laurie J Minze, Wei Xue, Wenhao Chen, Molecular insights into the development of T cell-based immunotherapy for prostate cancer Expert Review of Clinical Immunology. ,vol. 10, pp. 1547- 1557 ,(2014) , 10.1586/1744666X.2014.962515
Katia Beider, Michal Abraham, Amnon Peled, Chemokines and chemokine receptors in stem cell circulation Frontiers in Bioscience. ,vol. Volume, pp. 6820- 6833 ,(2008) , 10.2741/3190
Graham Simmons, Stephanie Bertram, Ilona Glowacka, Imke Steffen, Chawaree Chaipan, Juliet Agudelo, Kai Lu, Andrew J. Rennekamp, Heike Hofmann, Paul Bates, Stefan Pöhlmann, Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion Virology. ,vol. 413, pp. 265- 274 ,(2011) , 10.1016/J.VIROL.2011.02.020
Fabio M V Rossi, Stephane Y Corbel, Jasmeen S Merzaban, Douglas A Carlow, Klaus Gossens, Jeffrey Duenas, Leslie So, Lin Yi, Hermann J Ziltener, Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nature Immunology. ,vol. 6, pp. 626- 634 ,(2005) , 10.1038/NI1203
KANG HAN, TINGBAO ZHAO, XIANG CHEN, NA BIAN, TONGTAO YANG, QIONG MA, CHENGKUI CAI, QINGYU FAN, YONG ZHOU, BAOAN MA, microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R International Journal of Oncology. ,vol. 45, pp. 1437- 1449 ,(2014) , 10.3892/IJO.2014.2571
Aaron M. Sargeant, Russell D. Klein, Robert C. Rengel, Steven K. Clinton, Samuel K. Kulp, Yoko Kashida, Mamoru Yamaguchi, Xingya Wang, Ching-Shih Chen, Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicologic Pathology. ,vol. 35, pp. 549- 561 ,(2007) , 10.1080/01926230701338966