The role of B cells in the pathogenesis of graft-versus-host disease.

摘要: Allogeneic hematopoietic stem cell transplantation is an established treatment modality for malignant and nonmalignant hematologic diseases. Acute chronic graft-versus-host diseases (GVHDs) are a major cause of morbidity mortality after allogeneic transplantation. T cells have been identified as key players in the reaction and, therefore, most drugs used against GVHD target cells. Despite our knowledge on pathogenesis GVH reaction, success therapies prevention GHVD unsatisfactory. Recently, animal human studies demonstrated that B involved immunopathophysiology acute GVHD. Early phase clinical trials B-cell depletion with rituximab shown beneficial effects both This review summarizes current experimental evidence involvement discusses implications management patients undergoing