Endoscopic monitoring of Crohn's disease treatment: A prospective, randomized clinical trial

摘要: A randomized clinical trial was conducted to determine whether colonoscopy is useful in deciding how long maintain steroid treatment attacks of Crohn's disease involving the colon. One hundred forty-seven patients with acute colonic or ileocolonic were treated by oral prednisolone, 1 mg.kg-1.day-1; 136 achieved remission, but 96 them still had active endoscopic lesions and either immediate start tapering (group A; n = 46) continued prednisolone at same dosage for 5 more weeks before begun B; 50). In remaining 40 (already group C), immediately. After discontinuation, followed up 18 months until relapse. Prolongation therapy significantly improved scores B (30% remission). The frequency successful weaning almost identical groups (82% 80%, respectively), as actuarially calculated relapse rate after withdrawal (P 0.22). No factor predictive could be found. course C similar that those B. Overall, only 22% 147 remission off steroids outlining need maintenance therapy. conclusion, who have adjustment duration on basis endoscopy results no benefit, aspect has prognostic value; thus, it appears unnecessary repeat such begun.