Definitive hypofractionated radiotherapy for early glottic carcinoma: experience of 55Gy in 20 fractions.

摘要: A wide variety of fractionation schedules have been employed for the treatment early glottic cancer. The aim is to report our 10-year experience using hypofractionated radiotherapy with 55Gy in 20 fractions at 2.75Gy per fraction. Patients treated between 2004 and 2013 definitive a dose over 4 weeks T1/2 N0 squamous cell carcinoma glottis were retrospectively identified. prior therapeutic minor surgery (eg. laser stripping, cordotomy) included. probabilities local control, ultimate control (including salvage surgery), regional cause specific survival (CSS) overall (OS) calculated. One hundred thirty-two patients Median age was 65 years (range 33–89). follow up 72 months 7–124). 50 (38 %), 18 (14 %) 64 (48 had T1a, T1b T2 disease respectively. Five year rates were: - 85.6 % 97.3 respectively, T1a 91.8 100 %, 81.6 93.8 80.9 95.8 %. CSS OS 95.4 95.7 78.8 There no significant associations covariates (e.g. T-stage, extent laryngeal extension, histological grade) on univariate analysis. Only increasing transglottic extension significantly associated (both p <0.01). Second primary cancers developed 17 patients. 13 (9.8 required enteral tube feeding support during radiotherapy; long term nutrition. patient tracheostomy due non-functioning larynx up. Hypofractionated radiation therapy stage cancer provides high acceptable toxicity.