Structural and functional roles of glycosylphosphoinositides.

摘要: Many proteins are anchored to the cell surface by hydrophobic interactions with membrane bilayer. Several structural motifs utilized for anchorage in mammalian cells, including covalent attachment of lipids (Saltiel et al., 1991). One such mechanism involves linkage a glycosylated form phosphatidylinositol (PI), termed glycosylphosphatidylinositol (GPI). This has been detected variety types and is over 100 (Ferguson Williams, 1988; Low Saltiel, 1988). Additionally, glycophospholipid several similarities GPI anchor described number Cuatrecasas, 1986, Saltiel 1986). lipid, which shares core structure may represent biosynthetic intermediate, undergoes phospholipase C (PLC)-catalyzed hydrolysis response insulin functionally related growth factors, generating an aqueous glycan cells that mediates some actions hormone 1986; Although precise relationship between protein hormone-sensitive free lipid remains unknown, numerous suggest these glycolipids participate functions cellular regulation. chapter focuses on unusual properties important roles this unique class