Online Measurement of Exhaled NO Concentration and Its Production Sites by Fast Non-equilibrium Dilution Ion Mobility Spectrometry.
作者： Liying Peng , Dandan Jiang , Zhenxin Wang , Jiwei Liu , Haiyang Li
DOI: 10.1038/SREP23095
关键词:
摘要: Exhaled nitric oxide (NO) is one of the most promising breath markers for respiratory diseases. Its profile exhalation and NO production sites can provide useful information medical disease diagnosis therapeutic procedures. However, high-level moisture in exhaled gas always leads to poor selectivity sensitivity ion spectrometric techniques. Herein, a method based on fast non-equilibrium dilution mobility spectrometry (NED-IMS) was firstly proposed directly monitor line. The interference eliminated by turbulently diluting original 21% with drift gas. Weak enhancement observed humid response its limit detection at 100% relative humidity down 0.58 ppb. concentrations multiple flow rates were measured, while determined using two-compartment model (2CM) Hogman Merilainen algorithm (HMA). Last but not least, analyzed hourly tentatively investigate daily physiological process NO. results demonstrated capacity NED-IMS real-time analysis clinical assessment.
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