Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma.

摘要: Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It result executive dysfunction, memory impairment, depression suicidality, apathy, poor impulse control, eventually dementia. Beyond the risk factors for CTE remain unknown. neuropathologically characterized aggregation accumulation of hyperphosphorylated tau TDP-43. Recent postmortem findings indicate that may affect broader population than was initially conceptualized, particularly contact sport athletes those with history military combat. Given large could potentially affected, represent an important issue public health. Although there has been greater awareness brought condition recent years, are still many research questions remain. Thus far, can only diagnosed post-mortem. Current efforts focused on creation clinical diagnostic criteria, finding objective biomarkers CTE, understanding additional underlying mechanism causes disease. This review examines date suggests future directions worthy exploration.