Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain
作者： Matthew S. Alkaitis , Carlos Solorzano , Russell P. Landry , Daniele Piomelli , Joyce A. DeLeo
DOI: 10.1371/JOURNAL.PONE.0010891
关键词:
摘要: Background An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying transition from acute to states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors type 1 (CB1) and 2 (CB2). We have previously shown that intrathecal administration a CB2 receptor agonist reverses both incision-induced behavioral hypersensitivity associated over-expression spinal glial markers. therefore hypothesized endocannabinoid signaling promotes resolution postoperative modulating pro-inflammatory in cord cells.
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