Methods and pharmaceutical compositions for the treatment of non-alcoholic fatty liver disease

作者: Chantal Boulanger-Robert , Pierre-Emmanuel Rautou

DOI:

关键词:

摘要: The present invention relates to methods and pharmaceutical compositions for the treatment of non-alcoholic fatty liver disease. inventors showed that autophagy is defective in sinusoidal endothelial cells (LSECs) from patients with steatohepatitis (NASH) contributes main features this In particular, a method treating disease subject need thereof comprising administering therapeutically effective amount an agent capable restoring subject's cells.

参考文章(11)
Jin-Sun Kim, Sung Youb Jung, Sang Hyun Lee, Myung Hyun Jang, Se Chang Kwon, In Young Choi, Composition for treating hyperlipidemia comprising oxyntomodulin derivative ,(2013)
Shvetank Sharma, Jamie E. Mells, Ping P. Fu, Neeraj K. Saxena, Frank A. Anania, GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy PLoS ONE. ,vol. 6, pp. e25269- ,(2011) , 10.1371/JOURNAL.PONE.0025269
Jesse D. Riordan, Joseph H. Nadeau, Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse Mammalian Genome. ,vol. 25, pp. 473- 486 ,(2014) , 10.1007/S00335-014-9521-3
Chih-Wen Lin, Hao Zhang, Min Li, Xiwen Xiong, Xi Chen, Xiaoyun Chen, Xiaocheng C Dong, Xiao-Ming Yin, None, Pharmacological Promotion of Autophagy Alleviates Steatosis and Injury in Alcoholic and Non-alcoholic Fatty Liver Conditions in Mice Journal of Hepatology. ,vol. 58, pp. 993- 999 ,(2013) , 10.1016/J.JHEP.2013.01.011
Philippe Gallay, Luigi Naldini, Didier Trono, Inder Verma, Vector and method of use for nucleic acid delivery to non-dividing cells ,(1996)
Luigi Naldini, Deborah A. Farson, Thomas Dull, Rochelle Witt, Method and means for producing high titer, safe, recombinant lentivirus vectors ,(2000)
Mark J. Czaja, Function of Autophagy in Nonalcoholic Fatty Liver Disease Digestive Diseases and Sciences. ,vol. 61, pp. 1304- 1313 ,(2016) , 10.1007/S10620-015-4025-X
Satoshi Tanaka, Hayato Hikita, Tomohide Tatsumi, Ryotaro Sakamori, Yasutoshi Nozaki, Sadatsugu Sakane, Yuto Shiode, Tasuku Nakabori, Yoshinobu Saito, Naoki Hiramatsu, Keisuke Tabata, Tsuyoshi Kawabata, Maho Hamasaki, Hidetoshi Eguchi, Hiroaki Nagano, Tamotsu Yoshimori, Tetsuo Takehara, Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. Hepatology. ,vol. 64, pp. 1994- 2014 ,(2016) , 10.1002/HEP.28820
Pou Kuan Leong, Kam Ming Ko, Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity. ,vol. 2016, pp. 6171658- ,(2016) , 10.1155/2016/6171658