Valproate prevents the recurrence of absence status

作者: S. F. Berkovic , F. Andermann , A. Guberman , D. Hipola , P. F. Bladin

DOI: 10.1212/WNL.39.10.1294

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摘要: We assessed the value of valproate in prevention recurrent attacks absence status 25 patients. Eighteen patients had primary generalized epilepsy with a mean frequency 5.7 per year. After follow-up period 4.4 years, attack was reduced to 0.6 year (p less than 0.0005); 14 no recurrence, 3 rare noncompliance, and 1 an incomplete response probably due gastrointestinal intolerance. Patients evidence cerebral damage (n = 2) or EEG focalization 5) did not respond as favorably. Valproate is drug choice for recurrence status. Moreover, can be predicted on basis electroclinical subtype

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