T-Cell Mediated Immunomodulation and Transplant Optimization

摘要: T-cell mediated immune responses are decisive for the success or failure of transplantation. As a consequence, events have been first and oldest major target therapeutic efforts to optimize transplant survival. With cells, tissues, scaffolds, devices more often merged become medicinal products, i.e., tissue-engineered products combination advanced therapy product (ATMPs), understanding response may be valuable purpose this book pave way novel, smart strategies therapeutically modulate infiltrating reducing side effects improving outcome, healing, tissue restoration, In chapter, current novel concepts immunomodulation their clinical translation will presented discussed allow transfer knowledge gained implanted materials as well ATMPs. Starting from hypothesis similarities differences between classical those directed against scaffolds devices, mechanisms behind in tolerance rejection unraveled control T-cells front proposed.