The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy

作者: Shiyu Song , Paul Dent , Steven Grant

DOI: 10.1007/978-3-540-74386-6_11

关键词:

摘要: The development of a large number targeted agents has introduced tremendous opportunities as well challenges to the field oncology. Although most show limited single drug potential for cure common solid neoplasms, they can prolong patient survival in selected tumor types and, importantly, enhance existing therapies variety cancers. Improvements have been achieved treatment hematological malignancies, colorectal cancer, renal lung head and neck breast liver cancer. Because these do not cause side effects similar those cytotoxic drugs radiation therapy, their combination with current conventional chemotherapy radiotherapy is usually feasible. How best combine new requires intensive persistent efforts from both clinicians research scientists.

参考文章(202)
David E. Gerber, Targeted therapies: a new generation of cancer treatments. American Family Physician. ,vol. 77, pp. 311- 319 ,(2008)
Adrian M. Senderowicz, Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Investigational New Drugs. ,vol. 17, pp. 313- 320 ,(1999) , 10.1023/A:1006353008903
Jeung-Whan Han, Hoi Young Lee, Seung Hee Park, Dong-Wan Seo, Sungyoul Hong, Hyoung-Keun Kwon, Yin-Won Lee, Hyang-Woo Lee, So Young Wang, Gyu-Un Bae, Seong Hoon Ahn, Apicidin, a Histone Deacetylase Inhibitor, Inhibits Proliferation of Tumor Cells via Induction of p21WAF1/Cip1 and Gelsolin Cancer Research. ,vol. 60, pp. 6068- 6074 ,(2000)
Lin-Feng Chen, Warner C. Greene, Shaping the nuclear action of NF-κB Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 392- 401 ,(2004) , 10.1038/NRM1368
Francesca DiStefano, David Robertson, Paul Andrew Clarke, Isabelle Hostein, Paul Workman, Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Research. ,vol. 61, pp. 4003- 4009 ,(2001)
Lin Tang, Paul Dent, Yun Dai, Victor Singh, Robert McInistry, Chunrong Yu, Zhiliang Wang, Steven Grant, Pharmacological Inhibitors of the Mitogen-activated Protein Kinase (MAPK) Kinase/MAPK Cascade Interact Synergistically with UCN-01 to Induce Mitochondrial Dysfunction and Apoptosis in Human Leukemia Cells Cancer Research. ,vol. 61, pp. 5106- 5115 ,(2001)
Michael B. Kastan, Cell cycle. Checking two steps. Nature. ,vol. 410, pp. 766- 767 ,(2001) , 10.1038/35071218
W. Gregory Alvord, Richard L. Klabansky, Gabriela Tudor, William Koss, John F. Greene, Sherman F. Stinson, Francisco Arguello, Timothy J. Siford, Mark Alexander, Edward A. Sausville, Erik M. Smith, Judith A. Sterry, Naina T. Kalavar, C. David Morgan, Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts Blood. ,vol. 91, pp. 2482- 2490 ,(1998) , 10.1182/BLOOD.V91.7.2482
Yves Pommier, Kurt W. Kohn, Tsunehiro Shimizu, Chun-Xia Cao, Rong-Guang Shao, Patrick M. O'Connor, Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function Cancer Research. ,vol. 57, pp. 4029- 4035 ,(1997)
Peng Huang, Li Feng, Elizabeth A. Oldham, Michael J. Keating, William Plunkett, Superoxide dismutase as a target for the selective killing of cancer cells Nature. ,vol. 407, pp. 390- 395 ,(2000) , 10.1038/35030140