Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit.

摘要: The indispensable requirement for metals in life processes has led to the evolution of sophisticated mechanisms that allow organisms maintain dynamic equilibria these ions. This control level, speciation, and availability a variety metal ions allows sustain biological while avoiding toxicity. When functioning properly, cells return their homeostatic set points following shifts or other stressors. These periods transition, when are state flux which they work regain homeostasis, present windows opportunity pharmacologically manipulate targets associated with metal-trafficking pathways ways could either facilitate homeostasis recovery cellular function further push outside into distress. purpose this Viewpoint is highlight emerging opportunities chemists chemical biologists develop compounds therapeutic benefit.