Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon.
作者： Theodore A. Slotkin , Edward D. Levin , Olga A. Timofeeva , Cindy S. Roegge , Frederic J. Seidler
DOI: 10.1016/J.NTT.2007.10.002
关键词:
摘要: Background Developmental neurotoxicity of organophosphorous insecticides (OPs) involves multiple mechanisms in addition to cholinesterase inhibition. We have found persisting effects developmental chlorpyrifos (CPF) and diazinon (DZN) on cholinergic serotonergic neurotransmitter systems gene expression as well behavioral function. Both molecular/neurochemical OP exposure been seen at doses below those which cause appreciable
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