Pharmacology of antidepressants: focus on nefazodone.

摘要: The past decade has witnessed the introduction of a diverse group antidepressants from variety distinct chemical classes, each with their own specificity for neurochemical transmitters, receptors, and cytochrome P450 isozymes. This review focuses on nefazodone, antidepressant efficacy treatment depression depression-related anxiety symptoms, an established tolerability profile, multimodal mechanism action. Relevant pharmacologic pharmacodynamic effects are summarized that support nefazodone as attractive choice both short- long-term depression.