A Review Report on Newer Advancement in Bioisosteric Replacement in Drug Design

作者: Shweta Srivastava , Yashasvi Jain , Yashbir Singh

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摘要: Bioisosteres are major challenge to change a compound with high affinity biological lead in successful drug. It showes one approach used by the pharmaceutical chemist for rational modification. The objective of bioisosteric replacement is modify new same properties original and improve structure activity relationship purity also.

参考文章(12)
David A. Walsh, Stephen K. Franzyshen, John M. Yanni, Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds. Journal of Medicinal Chemistry. ,vol. 32, pp. 105- 118 ,(1989) , 10.1021/JM00121A022
Ahsraf Saeed, Jeanie B. McMillin, Paul E. Wolkowicz, Wayne J. Brouillette, 3-Amino-5,5-dimethylhexanoic acid. Synthesis, resolution, and effects on carnitine acyltransferases Journal of Medicinal Chemistry. ,vol. 37, pp. 3247- 3251 ,(1994) , 10.1021/JM00046A008
Qun Sun, Barbara Gatto, Chiang Yu, Angela Liu, Leroy F. Liu, Edmond J. LaVoie, Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors Journal of Medicinal Chemistry. ,vol. 38, pp. 3638- 3644 ,(1995) , 10.1021/JM00018A024
Franck Eydoux, Michael A Chlenov, Marius Réglier, None, Synthesis of indane derivatives as mechanism-based inhibitors of dopamine β-hydroxylase Bioorganic & Medicinal Chemistry Letters. ,vol. 5, pp. 941- 944 ,(1995) , 10.1016/0960-894X(95)00147-L
Danny L. Dunnx, Britt S. Scott, Edwin D. Dorsey, Analysis of Pilocarpine and Isopilocarpine in Ophthalmic Solutions by Normal-Phase High-Performance Liquid Chromatography Journal of Pharmaceutical Sciences. ,vol. 70, pp. 446- 449 ,(1981) , 10.1002/JPS.2600700427
Per Sauerberg, June Chen, Elizabeth WoldeMussie, Henry Rapoport, Cyclic carbamate analogues of (+)-pilocarpine Journal of Medicinal Chemistry. ,vol. 32, pp. 1322- 1326 ,(1989) , 10.1021/JM00126A030
T. UNO, H. KONDO, Y. INOUE, Y. KAWAHATA, M. SOTOMURA, K. IUCHI, G. TSUKAMOTO, Synthesis of Antimicrobial Agents. Part 3. Syntheses and Antibacterial Activities of 7-(4-Hydroxypiperazin-1-yl)quinolones. ChemInform. ,vol. 22, ,(1991) , 10.1002/CHIN.199110194