Proteomic analyses identify prognostic biomarkers for pancreatic ductal adenocarcinoma.
作者： Dingyuan Hu , Daniel Ansari , Krzysztof Pawłowski , Qimin Zhou , Agata Sasor
DOI: 10.18632/ONCOTARGET.23929
关键词:
摘要: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Here we show that shotgun and targeted protein sequencing can be used to identify potential prognostic biomarkers in formalin-fixed paraffin-embedded specimens from 9 patients with PDAC "short" survival ( 45 months) undergoing surgical resection. A total of 24 147 proteins were significantly upregulated [fold change ≥2 or ≤0.5 P<0.05; different detection frequencies (≥5 samples)] (including GLUT1) "long" C9orf64, FAM96A, CDH1 CDH17), respectively. STRING analysis these indicated tight protein-protein interaction network centered on TP53. Ingenuity pathway linked representing "activated stroma factors" "basal tumor poor prognosis PDAC. It also highlighted TCF1 CTNNB1 as possible upstream regulators. Further parallel reaction monitoring verified seven (MMP9, CLIC3, MMP8, PRTN3, P4HA2, THBS1 FN1), while 18 survival, including EPCAM, LGALS4, VIL1, CLCA1 TPPP3. Thus, 25 biomarker candidates for at the tissue level. Furthermore, an activated status interactions TP53 might
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