Diagnostic value of diffusion-weighted magnetic resonance imaging compared with fluorodeoxyglucose positron emission tomography/computed tomography for pancreatic malignancy: a meta-analysis using a hierarchical regression model.

摘要: Background and Aim:  To obtain diagnostic performance of diffusion-weighted magnetic resonance imaging (DWI) fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the detection pancreatic malignancy. Methods:  We performed a meta-analysis all available studies DWI PET/CT for malignancy. MEDLINE, EMBASE, Cochrane library some other databases were searched initial studies. determined sensitivities specificities across studies, calculated positive negative likelihood ratios (LR+ LR−), constructed summary receiver operating characteristic curves (SROC) using hierarchical regression models. Results:  Across 16 with 804 patients, sensitivity was 0.87 (95% confidence interval [CI], 0.82, 0.81) specificity 0.83 CI, 0.71, 0.91). Overall, LR+ 5.84 4.59, 7.42) LR− 0.24 0.17, 0.33). 0.85 0.74, 0.92) 0.91 0.98). 9.53 2.41, 37.65) 0.17 0.09, 0.32). In subgroup analysis, enhanced versus unenhanced cancer 0.86, 0.96) 0.84 0.78, 0.90) (P > 0.05), 0.88 0.73, 1.00) 0.81 0.69, 0.94) (P > 0.05). Conclusion:  Positron highly sensitive specific modality diagnosing patients could play different roles carcinoma. Enhanced seems to be superior PET/CT. Further larger prospective are needed establish its value diagnosis cancer.