Attenuated Central Pressor Response to Nitric Oxide Synthesis Inhibition in Chronic Renal Failure Rats

摘要: OBJECTIVES Central and peripheral roles of nitric oxide (NO) in blood pressure regulation have been suggested. The present study was aimed at examining if the role NO is altered chronic renal failure. METHODS Blood responses to acute inhibition were examined 5/6 nephrectomized rats. Three weeks after ablation, under thiopental (50 mg/kg, i.p.) anesthesia, an intracerebroventricular cannula placed left lateral ventricle femoral vein cannulated serve as infusion route. arterial measured right artery. NG-nito-L-arginine methyl ester (L-NAME) infused (100 microgram/kg per min for 60 either intracerebroventricularly or intravenously. RESULTS Chronic failure rats showed a significantly higher than control (147 +/- 14 mmHg vs. 122 13 mmHg). Intracerebroventricular L-NAME did not affect (0.5 4 increase from basal), while it increased normal (22 3 increases basal). Intravenous pressure, magnitude which differ between (24 16 CONCLUSION These results indicate that central