Cell-penetrating peptide enhanced intracellular Raman imaging and photodynamic therapy.
作者： Andrew M. Fales , Hsiangkuo Yuan , Tuan Vo-Dinh
DOI: 10.1021/MP300634B
关键词:
摘要: We present the application of a theranostic system combining Raman imaging and photodynamic therapy (PDT) effect. The nanoplatform was created by loading photosensitizer, protoporphyrin IX, onto Raman-labeled gold nanostar. A cell-penetrating peptide, TAT, enhanced intracellular accumulation nanoparticles in order to improve their delivery efficacy. plasmonic nanostar platform designed increase signal via surface-enhanced resonance scattering (SERRS) Theranostic SERS using this construct were demonstrated on BT-549 breast cancer cells. TAT peptide allowed for effective photosensitization with nanoparticle after 1 h incubation period. In absence cells not sufficient be observed or produce any effect short There no cytotoxic ef...
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