Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR

摘要: HuR emerged as a posttranscriptional regulator of mRNAs involved in cellular control, stress, and immunity but its role governing such responses remains elusive. In this study, we assessed HuR’s the staged progression thymic T cell differentiation by means genetic ablation. Mice with an early deletion thymocytes possess enlarged thymi display substantial loss peripheral cells. We show that discordant phenotype related to specific defects processes, which demonstrated involvement in: 1) intrinsic checkpoint signals suppressing cycle immature thymocyte progenitors, 2) TCR antigenic promoting activation positive selection mature thymocytes, 3) death-receptor deletion, 4) chemokine driving egress postselection periphery. The consequences dysfunction were underlined aberrant expression selective regulators, TCR, signaling components. Our studies reveal signal-dependent context activities importance generation physiological pool.