Education in atherothrombosis

摘要: The prevalence of atherothrombosis and the incidence its various clinical manifestations in Europe rest world is such that a huge amount resource committed to enhancing our understanding causes improving treatment prevention. range increasing effectiveness cardiovascular drugs are available assist prevention management has now provided physicians with an impressive number options which continues expand as each year passes. This delivers challenge scientific communities how best disseminate knowledge order direct future research endeavours maximise impact therapeutic advances. We have rich variety media through can be spread, including original review articles paper online form, guidelines, updates position papers societies European Society Cardiology, American College Cardiology Heart Association (also printed electronic form), books, conferences (often presentations or other digital media), websites specialising research, theHeart.org Cardiosource, materials by pharmaceutical device industries. complexity many areas relating gives platform individuals expert who guide way consensus. Yet herein lies perceived danger attracted much attention: commercial forces behind drug development potential influence opinion could bias presentation data for gain (1, 2). Whatever level disclosure, reader educational must identify themselves likely article (3) prepared probe deeper into literature form on evidence particular intervention else rely trusted source. supplement was supported unrestricted grant academic institution from industry. type support take guises but this case companies had no part constructing not reviewed approved content. clearly prerequisite minimising risk bias. Furthermore been submitted formal peer-review process. aspiration process high-quality communities, accessible freeof-charge via internet, inform debates well decision-making increasingly complex primary secondary therapies. hope readers will judge authors succeeded meeting aim. Numerous animal models studying roles different cell types extracellular molecules arterial thrombosis sequelae. Mouse advantage availability study feasibility genetic knock-out lines characterise role platelet receptor pathways coagulation proteins complement substantiate pharmacological studies. For example, P2Y12 knockout mice confirmed Correspondence to: Prof. Robert F. Storey, MD University Sheffield Department Cardiovascular Science Beech Hill Road, South Yorkshire, S10 2RX, UK Tel.: +44 114 2713964, Fax: 2711863 E-mail: r.f.storey@sheffield.ac.uk