Determination of simvastatin, pravastatin sodium and rosuvastatin calcium in tablet dosage forms by HPTLC

摘要: Simple and reproducible HPTLC method was developed for the separation quantitation of simvastatin, pravastatin sodium rosuvastatin calcium, cholesterol lowering agents in pharmaceutical dosage forms. The stationary phase used precoated silica gel 60F 254 . mobile a mixture chloroform:methanol:toluene (6:2:2, v/v/v). has been completely validated proved to be rugged. Calibration curves were linear over studied ranges with correlation coefficients grater than 0.999. All drugs extracted from respective tablets using methanol. percentage recoveries ranged 100 101 98 102 calcium. LOD calcium found 15, 9 8 ng/spot, respectively LOQ 200 ng/spot simvastatin can useful quality control bulk manufacturing tablet