Quality by design and formulation optimization using statistical tools for safe and efficient bioactive loading

摘要: Abstract Innumerable techniques have been explored to fabricate delivery systems for bioactives/biologic agents. Major hindrance in the execution of these scale-up production is requirement defined steps including practicality process, excipient compatibility, process and formulation optimization, validation with a view achieve optimized yield. Different designing techniques, such as experimental design-factorial design, can be employed tools offer rational approach developing phases fabrication effectual systems. Thus desirable features successfully obtained by that are cost-effective, generating extreme information, understanding minimum number runs maximum reproducibility.