Positionspapier der DGK zur Wirksamkeit und Sicherheit von Medikamente freisetzenden Koronarstents (DES)
作者： S. Silber , M. Borggrefe , M. Böhm , H.M. Hoffmeister , R. Dietz
DOI: 10.1007/S12181-007-0012-6
关键词:
摘要: Hintergrund Die perkutane Koronarintervention (PTCA, PCI) ist die haufigste Art der myokardialen Revaskularisation. Da routinemasige Stentimplantation den klinischen Verlauf verbessert, sie heute Standard. Die aus Edelstahl gefertigten Koronarstents induzieren eine Gewebsreaktion im Sinn einer Intimahyperplasie. Diese oft uberschiesend und fuhrt zu letztendlich iatrogenen Krankheit: In-Stent-Restenose. Medikamente freisetzende (Drug-eluting-Stents, DES) reduzieren aufgrund ihrer Abgabe antiproliferativer Substanzen Haufigkeit von In-Stent-Restenosen in einem klinisch relevanten Ausmas verhindern somit erneute Revaskularisationsmasnahmen. Ziel des vorliegenden Positionspapieres es, einen Uberblick uber aktuelle Studienlage zur Wirksamkeit Sicherheit DES geben.
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