Liver metastases as a first manifestation of gastrointestinal stromal tumour (GIST)

摘要: Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumour of gastrointestinal tract. Liver metastasis and diffuse intraabdominal spread typical manifestation advanced malignancy. A 59-year-old female patient was admitted to Internal Department with synchronous liver metastases. Clinical examination revealed a palpable abdominal mass in left epigastrum. Gastroscopy an neoplasmatical stomach. The histological findings showed GIST strong CD117 CD34 reactivity. characterised by oncogenic mutations KIT receptor tyrosine kinase. Imatinib (tyrosine kinase inhibitor) used treatment metastatic GIST.