Glia-Synapse Interaction Through Ca2+-Permeable AMPA Receptors in Bergmann Glia
作者： M. Iino
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摘要: Glial cells express a variety of neurotransmitter receptors. Notably, Bergmann glial in the cerebellum have Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)–type glutamate receptors (AMPARs) assembled without GluR2 subunit. To elucidate role these AMPARs, we converted them into Ca2+-impermeable by adenoviral-mediated delivery gene. This conversion retracted processes ensheathing synapses on Purkinje cell dendritic spines and retarded removal synaptically released glutamate. Furthermore, it caused multiple innervation climbing fibers. Thus, AMPARs are indispensable for proper structural functional relations between glia glutamatergic synapses.
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